Preparation lines

Preparation lines


Pharmaceutical solutions are liquid preparations containing one or more substances dissolved in the molecular state, in a solvent or mixture of solvents. When the final drug is an injectable, WFI is commonly used as the solvent.
BRAM-COR is able to provide the most appropriate process solutions for the production of

  • Injectable solutions and solutions for infusions
  • Dermal solutions
  • Oral solutions
  • Solutions for inhalations

The long experience of BRAM-COR in pharmaceutical processing has enabled the development of a wide range of tanks and filtration systems dedicated to

  • Formulation / mixing / homogenization
  • Sterile filtration
  • Transfer and storage


BRAM-COR range of tanks offers a variety of customizable options based on the required process, regulatory requirements and production technology.

Preparation lines


Dispersions are biphasic systems with two substances, one called dispersed/discontinuous phase that is distributed in the form of particles or droplets throughout another substance called continuous, dispersant, or external phase.

BRAM-COR  processing technology is used to produce pharmaceutical dispersions in their most-used form called suspension (where solid particles are insoluble in the dispersing medium). The technology can be used for:
  • Suspensions for oral use
  • Suspensions for topical use
  • Suspensions for injectable use
  • Emulsions (made up of 2/3 components and immiscible liquid phases, one of which is dispersed in the other)

BRAM-COR emulsifiers are engineered to manage the particle size distribution (in both productions), specifically for parenteral and ophthalmic suspension where stability is a determining factor. Our high shear mixers are also used to obtain finer particle sizes processing emulsions to avoid phenomena such as sedimentation and aggregation of particles.

Preparation lines


Semi-solid pharmaceutical forms are suitable for the treatment of skin disorders and are mainly designed for topical use. The following are the main groups of semisolid preparations

  • Ointments: consist of a monophasic base, in which solid and/or liquid substances can be dispersed. This type of drug formulated to allow the skin penetration of the active ingredients dispersed in the drug, or to provide an emollient, lubricating or protective action;
  • Creams: multiphase preparations consisting of a lipophilic phase and an aqueous phase; they are generally formulated as either water-in-oil or oil-in-water emulsions
  • Gels: semi-solid preparations that contain small inorganic particles or large organic molecules that form a lattice to retain the dispersing liquid phase
  • Pastes: semi-solid preparations for dermal/topical application that contain solids in large percentages/quantity, finely dispersed in a base (in general, the percentage of dispersed solid is between 30% and 70%). They are characterized by high viscosity.

The homogenization and micronization of the product particles play a crucial role in the manufacturing process of semi-solid drugs. The two processes provide better dermal absorption at the time of application.

The manufacturing process of semi-solid products generally consists of the following steps:

  • Preparation of the fat/oil phase
  • Preparation of the liquid/aqueous phase
  • Mixing phase of the previously described processes with homogenization and final micronization

BRAM-COR’s experience in pharmaceutical processing has ensured the development of a wide range of process equipment dedicated to handle these types of viscous preparations